What is L-Citrulline?

L-Citrulline is a naturally occurring amino acid and key intermediate in the urea cycle. It is found naturally in foods such as watermelon and is produced endogenously in the body. L-Citrulline is widely used as a dietary supplement ingredient across sports nutrition, functional food, and beverage applications. Its multifunctional properties include:

• Nitric Oxide (NO) Support: L-Citrulline is a precursor to L-Arginine in the kidneys, supporting the body’s nitric oxide synthesis pathway. Nitric oxide plays a key role in vasodilation and cardiovascular function.
• Sports & Exercise Performance: Commonly used in pre-workout and recovery formulations. Research suggests L-Citrulline may help reduce muscle fatigue and support high-intensity exercise performance.
• Flavor Profile Enhancement: L-Citrulline carries a mild, slightly sweet taste, which can complement the flavor profile of beverages and nutrition products without contributing significant calories or sugar.
• Nutritional Fortification: Used in protein bars, nutritional drinks, and functional foods to enhance amino acid profiles and support labeling claims.

L-Citrulline Technical & Product Specifications

Regulatory & Handling Considerations

• Dietary Supplement Status (USA): L-Citrulline is classified as a dietary ingredient under the Dietary Supplement Health and Education Act (DSHEA). Suppliers and manufacturers are responsible for ensuring compliance with applicable FDA regulations for dietary supplements, including New Dietary Ingredient (NDI) notification requirements where applicable.
• Food Use & GRAS Considerations: When incorporated into conventional food and beverage products, L-Citrulline use should be evaluated under FDA’s GRAS framework. Manufacturers are advised to consult regulatory guidance or seek qualified expert review for intended use levels and applications.
• Stability: L-Citrulline is generally stable under ambient conditions. It is hygroscopic and should be stored sealed in a cool, dry environment away from direct light and moisture to maintain purity and flow properties.
• Ingredient Interactions: L-Citrulline is compatible with most food and supplement ingredients. Formulation considerations should account for its interaction with other amino acids and its conversion to L-Arginine in vivo, which may amplify effects when combined with other nitric oxide-supporting ingredients. Please contact our formulation team for application-specific guidance.
• Labeling: Must be declared as “L-Citrulline” on supplement facts panels or ingredient lists in the U.S. per applicable FDA labeling regulations.

About American International Foods, Inc. (AIFI) - A L-Citrulline Supplier & Distributor

American International Foods, Inc. is a leading L-Citrulline supplier with an additional full-service portfolio of over 2500 food and beverage ingredients. We offer one of the most extensive lines of amino acids distributed to manufacturers and processors in the food, beverage, pet food, health and nutrition sectors. With a strategic nationwide warehouse network and our reliable just-in-time deliveries, we can supply your business with high quality amino acids at competitive prices.